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CD4+CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapy
- Source :
- Blood Advances; July 2024, Vol. 8 Issue: 13 p3562-3575, 14p
- Publication Year :
- 2024
-
Abstract
- •Exhausted CD4+CAR T cells, identified by single-cell assays in the patients’ blood and marrow, is linked to early relapse.•Myeloid cells in the myeloma niche blunt CD4+CAR T-cell killing via transforming growth factor β.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Volume :
- 8
- Issue :
- 13
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs65994921
- Full Text :
- https://doi.org/10.1182/bloodadvances.2023012416