B-cell–directed CAR T-cell therapy activates CD8+cytotoxic CARnegbystander T cells in patients and nonhuman primates

•Transcriptomic analysis of NHP and patient-derived T cells following CAR T-cell infusion identified activated CAR−bystander CD8+T cells.•Cytokine exposure–induced bystander-like CD8+T cells capable of T-cell receptor–independent cytotoxic killing of leukemia cells.