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Longitudinal Tumor-informed Circulating Tumor DNA Status Predicts Disease Upstaging and Poor Prognosis for Patients Undergoing Radical Cystectomy

Authors :
Ben-David, Reuben
Tillu, Neeraja
Cumarasamy, Shivaram
Alerasool, Parissa
Rich, Jordan M.
Kaufmann, Basil
Elkun, Yuval
Attalla, Kyrollis
Mehrazin, Reza
Wiklund, Peter
Sfakianos, John P.
Source :
European Urology Oncology; October 2024, Vol. 7 Issue: 5 p1105-1112, 8p
Publication Year :
2024

Abstract

Circulating tumor DNA (ctDNA) status before cystectomy can be used as a prognostic marker for disease recurrence and can predict lymph node involvement and locally advanced disease. Incorporation of ctDNA into clinical practice could help in guiding treatment intensification or deintensification.

Details

Language :
English
ISSN :
25889311
Volume :
7
Issue :
5
Database :
Supplemental Index
Journal :
European Urology Oncology
Publication Type :
Periodical
Accession number :
ejs65689274
Full Text :
https://doi.org/10.1016/j.euo.2024.03.002