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Transition-Metal-Free C–N Cross-Coupling Enabled by a Multifunctional Reagent
- Source :
- Journal of the American Chemical Society; March 2024, Vol. 146 Issue: 10 p6476-6480, 5p
- Publication Year :
- 2024
-
Abstract
- We report the design and development of a transition-metal-free cross-coupling reaction of phenols and primary amines using a simple and readily available multifunctional reagent. The reactions work by induced proximity and electronic activation of both the nucleophile and the electrophile for net dehydrative C–N coupling reactions. Notably, the reactions do not involve the use of a transition metal for C–N bond formation, preactivation of the phenol electrophile, or exclusion of air or moisture. The mild conditions tolerate a broad range of functional groups and allow for this to be applied to the late-stage functionalization of complex substrates with a wide scope of coupling partners.
Details
- Language :
- English
- ISSN :
- 00027863 and 15205126
- Volume :
- 146
- Issue :
- 10
- Database :
- Supplemental Index
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Periodical
- Accession number :
- ejs65666335
- Full Text :
- https://doi.org/10.1021/jacs.4c00871