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Synthesis of biheteroaryls via2-methyl quinoline C(sp3)-H functionalization under metal-free conditions
- Source :
- Green Synthesis and Catalysis; February 2024, Vol. 5 Issue: 1 p73-76, 4p
- Publication Year :
- 2024
-
Abstract
- An acetic acid-promoted C(sp3)-H functionalization of 2-methyl quinoline, enaminoesters and elemental sulfur for the synthesis of 3,4,5-trisubstituted isothiazoles under metal-free conditions has been developed. This approach provides viable access to various 5-(quinolin-2-yl)isothiazoles in moderate to good yields with good functional group tolerance. Moreover, the success of the gram-scale reaction gives this reaction a great potential application.
Details
- Language :
- English
- ISSN :
- 26665549
- Volume :
- 5
- Issue :
- 1
- Database :
- Supplemental Index
- Journal :
- Green Synthesis and Catalysis
- Publication Type :
- Periodical
- Accession number :
- ejs65584321
- Full Text :
- https://doi.org/10.1016/j.gresc.2022.10.006