Reshaping of Local Alloimmunity By Organ-Specific Microenvironments during Acute Gvhd.

Following allogeneic hematopoietic cell transplantation (alloHCT) donor T cells infiltrate and damage multiple target organs, resulting in acute GVHD (aGVHD). However, the critical biological mechanisms underpinning the tissue-specificity of aGVHD remains only partially understood. Deciphering the organ-specific alloimmune mechanisms responsible for target organ damage offers new prospects for precisely targeted treatments for acute GVHD, minimizing impact on protective immunity and reducing overall toxicity.