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Distinct Leukocyte Populations and Cytokine Secretion Profiles Define Tumoral and Peritumoral Areas in Renal Cell Carcinoma
- Source :
- Translational Oncology; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- •Tumor-infiltrating lymphocytes (TILs) exhibit higher cytokine production compared to peripheral TILs (pTILs) in patients with RCC.•CD8+ T cells predominantly utilize Fas Ligand, while CD4+ T cells rely on CD107a for cytotoxicity in RCC.•The migration capacity of tumor-infiltrating lymphocytes (TILs) is inversely correlated with the proportion of cancer-associated fibroblasts (CAFs).•Tumor and peritumoral T cells exhibit limited responsiveness to additional activation signals, while peripheral T cells in circulation retain their capacity to respond to stimulatory signals.
Details
- Language :
- English
- ISSN :
- 19447124 and 19365233
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Translational Oncology
- Publication Type :
- Periodical
- Accession number :
- ejs65381450
- Full Text :
- https://doi.org/10.1016/j.tranon.2024.101891