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THBS1+myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1
- Source :
- Cell Reports; 20240101, Issue: Preprints
- Publication Year :
- 2024
-
Abstract
- Hepatocellular carcinoma (HCC) is an inflammation-associated cancer arising from viral or non-viral etiologies including steatotic liver diseases (SLDs). Expansion of immunosuppressive myeloid cells is a hallmark of inflammation and cancer, but their heterogeneity in HCC is not fully resolved and might underlie immunotherapy resistance. Here, we present a high-resolution atlas of innate immune cells from patients with HCC that unravels an SLD-associated contexture characterized by influx of inflammatory and immunosuppressive myeloid cells, including a discrete population of THBS1+regulatory myeloid (Mreg) cells expressing monocyte- and neutrophil-affiliated genes. THBS1+Mregcells expand in SLD-associated HCC, populate fibrotic lesions, and are associated with poor prognosis. THBS1+Mregcells are CD163+but distinguished from macrophages by high expression of triggering receptor expressed on myeloid cells 1 (TREM1), which contributes to their immunosuppressive activity and promotes HCC tumor growth in vivo. Our data support myeloid subset-targeted immunotherapies to treat HCC.
Details
- Language :
- English
- ISSN :
- 22111247
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Cell Reports
- Publication Type :
- Periodical
- Accession number :
- ejs65377079
- Full Text :
- https://doi.org/10.1016/j.celrep.2024.113773