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Plasmin-cleaved von Willebrand factor as a biomarker for microvascular thrombosis

Authors :
El Otmani, Hinde
Frunt, Rowan
Smits, Simone
Barendrecht, Arjan D.
de Maat, Steven
Fijnheer, Rob
Lenting, Peter J.
Tersteeg, Claudia
Source :
Blood; May 2024, Vol. 143 Issue: 20 p2089-2098, 10p
Publication Year :
2024

Abstract

•We developed a method to detect plasmin-cleaved VWF (cVWF) in plasma.•cVWF forms during attacks of microthrombosis in a mouse model of thrombotic thrombocytopenic purpura and in human patients.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
143
Issue :
20
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs65351328
Full Text :
https://doi.org/10.1182/blood.2023021265