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Dual-targeting CD33/CD123 NANOBODY T-cell engager with potent anti-AML activity and good safety profile
- Source :
- Blood Advances; May 2024, Vol. 8 Issue: 9 p2059-2073, 15p
- Publication Year :
- 2024
-
Abstract
- •CD33/CD123 NANOBODY TCE kills single and double-positive cells, outperforming single-targeting TCE in a subset of AML samples.•CD33/CD123-TCE efficiently kills AML cells in a mouse model and targets cells in nonhuman primates without signs of cytokine release.
Details
- Language :
- English
- ISSN :
- 24739529 and 24739537
- Volume :
- 8
- Issue :
- 9
- Database :
- Supplemental Index
- Journal :
- Blood Advances
- Publication Type :
- Periodical
- Accession number :
- ejs65327948
- Full Text :
- https://doi.org/10.1182/bloodadvances.2023011858