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TMSOTf-Promoted Cyclization of Indole-2-methyl-α-aminoketones: Access to 4-Aryl-Substituted β-Carbolines
- Source :
- Organic Letters; February 2024, Vol. 26 Issue: 5 p1105-1109, 5p
- Publication Year :
- 2024
-
Abstract
- An efficient method to construct 4-aryl-substituted β-carbolines from indole-2-methyl-α-aminoketones via a TMSOTf-promoted annulation reaction was reported. High yield along with wide substrate scope and functional group tolerance make this reaction applicable to build various highly potential bioactive β-carboline derivatives.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Volume :
- 26
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs65322652
- Full Text :
- https://doi.org/10.1021/acs.orglett.3c04382