A Multifunctional Hydrogel for Simultaneous Visible H2O2Monitoring And Accelerating Diabetic Wound Healing

Diabetic wound is one of the chronic wounds that is difficult to heal, and effective treatment of it still confronts a great challenge. Monitoring the variation of diabetic wound microenvironment (such as hydrogen peroxide (H2O2)) can understand the wound state and guide the wound management. Herein, a multifunctional hydrogel with the abilities of monitoring the H2O2concentration, alleviating oxidative stress and promoting wound healing is developed, which is prepared by encapsulating manganese‐containing bioactive glass (MnBG) and CePO4:Tb in biocompatible gelatin methacryloyl (GelMA) hydrogel (CPT‐MnBG‐Gel). On the one hand, the H2O2‐dependent fluorescence quenching effect of the CePO4:Tb contributes to visible monitoring of the H2O2concentration of wounds via smartphone imaging, and the CPT‐MnBG‐Gel hydrogel can effectively monitor the H2O2level of 10.35–200 µmol L−1. On the other hand, MnBG can alleviate oxidative stress and promote the proliferation, migration and differentiation of fibroblasts and endothelial cells in vitro owing to the bioactive Mn and Si ions, and in vivo evaluation also demonstrates that the CPT‐MnBG‐Gel hydrogels can effectively accelerate wound healing. Hence, such multifunctional hydrogel is promising for diabetic wound management and accelerating wound healing. A H2O2‐responsive smart hydrogel (CPT‐MnBG‐Gel) consists of GelMA hydrogel, MnBG, and CePO4:Tb particles is successfully prepared, which can alleviate oxidative stress and promote proliferation, migration, and differentiation of fibroblasts and endothelial cells. Such CPT‐MnBG‐Gel hydrogel can be applied as a multifunctional dressing for diabetic wound management and accelerating wound healing.