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A Prospective Analysis of Cholestasis in Infants Supported with Extracorporeal Membrane Oxygenation
- Source :
- Journal of Pediatric Gastroenterology & Nutrition; October 1991, Vol. 13 Issue: 3 p285-289, 5p
- Publication Year :
- 1991
-
Abstract
- Summary: Cholestasis develops in many infants supported with extracorporeal membrane oxygenation. We prospectively investigated the role of hemolysis and di-(2-ethylhexyl) phthalate exposure in the development of this cholestasis. Both di-(2-ethylhexyl) phthalate levels and hemolysis, as measured by maximum free hemoglobin, were significantly (p < 0.025) associated with the degree of cholestasis. Other clinical and laboratory factors that may contribute to cholestasis were also investigated and not found to be related to the degree of cholestasis. We speculate that hemolysis during extracorporeal membrane oxygenation support produces a large bilirubin load whose excretion is inhibited by mechanisms similar to the inspissated bile syndrome and/or by di-(2-ethylhexyl) phthalate. This would result in a predominantly direct hyperbilirubinemia with little evidence of hepatocellular or canalicular injury.
Details
- Language :
- English
- ISSN :
- 02772116 and 15364801
- Volume :
- 13
- Issue :
- 3
- Database :
- Supplemental Index
- Journal :
- Journal of Pediatric Gastroenterology & Nutrition
- Publication Type :
- Periodical
- Accession number :
- ejs65090708
- Full Text :
- https://doi.org/10.1002/j.1536-4801.1991.tb10342.x