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Microbiome–Epigenome Interactions and the Environmental Origins of Inflammatory Bowel Diseases
- Source :
- Journal of Pediatric Gastroenterology & Nutrition; February 2016, Vol. 62 Issue: 2 p208-219, 12p
- Publication Year :
- 2016
-
Abstract
- The incidence of pediatric inflammatory bowel disease (IBD), which includes Crohn disease and ulcerative colitis, has risen alarmingly in the Western and developing world in recent decades. Epidemiologic (including monozygotic twin and migrant) studies highlight the substantial role of environment and nutrition in IBD etiology. Here we review the literature supporting the developmental and environmental origins hypothesis of IBD. We also provide a detailed exploration of how the human microbiome and epigenome (primarily through DNA methylation) may be important elements in the developmental origins of IBD in both children and adults.
Details
- Language :
- English
- ISSN :
- 02772116 and 15364801
- Volume :
- 62
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Journal of Pediatric Gastroenterology & Nutrition
- Publication Type :
- Periodical
- Accession number :
- ejs65090244
- Full Text :
- https://doi.org/10.1097/MPG.0000000000000950