Restrictor synergizes with Symplekin and PNUTS to terminate extragenic transcription

In this study, Russo et al. describe the functional synergy between the adaptor protein Symplekin, the protein phosphatase 1 (PP1) regulatory subunit (PNUTS), and the Restrictor complex in controlling extragenic transcription termination in yeast. Their findings show that Symplekin is competitively recruited by Restrictor- or CPSF-containing transcription termination machineries and has a role in CPSF- and cleavage-independent transcriptional repression of noncoding RNAs and endogenous retroviral elements.