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Simple Score of Albumin and CRP Predicts High-Grade Toxicity in Patients with Multiple Myeloma Receiving CAR-T Therapy

Authors :
Akhtar, Othman S.
Modi, Karnav
Kim, Jongphil
Skelson, Lawrence
Smith, Eric
Al-Jumayli, Mohammed A.
Extermann, Martine
De Avila, Gabriel
Parker, Nathan
Castaneda Puglianini, Omar
Grajales Cruz, Ariel
Baz, Rachid
Blue, Brandon
Shain, Kenneth
Alsina, Melissa
Liu, Hien
Nishihori, Taiga
Jain, Michael D.
Locke, Frederick L.
Hansen, Doris K.
Freeman, Ciara L.
Source :
Transplantation and Cellular Therapy; March 2024, Vol. 30 Issue: 3 p283.e1-283.e10, 25480p
Publication Year :
2024

Abstract

•The Glasgow prognostic score (GPS) is a potent prognostic tool in malignancy.•In RRMM undergoing CAR-T, high-risk GPS had increased risk of grade 3 CRS and ICANS.•There was significant difference in day-100 OS between high-risk versus low-risk GPS.•GPS remained significant in multivariable models for day-100 overall survival.•GPS is a simple, powerful tool for identifying patients at higher risk from CART.

Details

Language :
English
ISSN :
26666375 and 26666367
Volume :
30
Issue :
3
Database :
Supplemental Index
Journal :
Transplantation and Cellular Therapy
Publication Type :
Periodical
Accession number :
ejs64956905
Full Text :
https://doi.org/10.1016/j.jtct.2023.12.010