Screening for Key Structural Differences in Thrombosis Versus Hemostasis through Single Platelet Analysis

INTRODUCTION: Taking a single platelet analysis (SPA) approach to score platelet activation states distribution within a thrombus provides a unique opportunity to examine cellular difference in the process of thrombotic versus hemostatic clot formation. Potentially, it may reveal platelet activation states are dispensable for hemostasis but critical for thrombosis, e.g., platelet infill within the interior cavities of thrombus. Hence, our goal of determining the distribution of platelet activation states and of a-granule content release in an occlusive clot compared to a hemostatic thrombus.