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Proteomic Profiling Identifies Unique IDH Mutant Signatures and Novel Therapeutic Opportunities in Adult Acute Myeloid Leukemia Patients

Authors :
de Camargo Magalhaes, Eduardo Sabino
Hubner, Stefan
Brown, Brandon D.
Qiu, Yihua
Kornblau, Steven M.
Source :
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p1581-1581, 1p
Publication Year :
2023

Abstract

Patients with IDH mutations are common in adult Acute Myeloid Leukemia (AML), with selective IDH inhibitors (IDHi) being recommended, but they do not always respond. We evaluated the proteome of IDH mutant AML patients to identify prognostic signatures and therapeutic targets.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
142
Issue :
1, Number 1 Supplement 1
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs64700195
Full Text :
https://doi.org/10.1182/blood-2023-186723