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Genomic Characterization of Acute Myeloid Leukemia with Aberrations of Chromosome 7: A Multinational Cohort of 523 Patients

Authors :
Halik, Adriane
Tilgner, Marlon
Silva, Patricia
Estrada-Barreras, Natalia
Altwasser, Robert
Jahn, Ekaterina
Heuser, Michael
Hou, Hsin-An
Pratcorona, Marta
Hills, Robert Kerrin
Metzeler, Klaus H
Fenwarth, Laurène
Dolnik, Anna
Terré, Christine
Kopp, Klara
Szyska, Martin
Krönke, Jan
Vasseur, Loïc
Lowenberg, Bob
Esteve, Jordi
Valk, Peter J. M.
Duchmann, Matthieu
Chou, Wen-Chien
Linch, David C.
Döhner, Hartmut
Gale, Rosemary E.
Döhner, Konstanze
Bullinger, Lars
Yoshida, Kenichi
Damm, Frederik
Source :
Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p63-63, 1p
Publication Year :
2023

Abstract

Introduction: Aberrations of chromosome 7 [abn(7)] are found in ≈ 10% of newly diagnosed acute myeloid leukemia (AML) and associate with a dismal prognosis. A large-scale comprehensive exploration of the underlying genetic heterogeneity in AML with abn(7) has yet to be performed and could add essential insights into the outcome of this poorly understood patient group.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
142
Issue :
1, Number 1 Supplement 1
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs64699265
Full Text :
https://doi.org/10.1182/blood-2023-185627