Back to Search
Start Over
High Exposure of Rabbit Anti-Thymocyte Globulin (ATG) Is Strongly Associated with Inferior DFS in Pediatric Patients with Malignancy Undergoing Alpha-Beta T-Cell Depleted Haploidentical HCT
- Source :
- Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p3533-3533, 1p
- Publication Year :
- 2023
-
Abstract
- The PTCTC ONC1401 trial reported a 75% 2-year disease-free survival (DFS) for pediatric patients with acute leukemia or MDS undergoing AB-TCR/CD19 depleted (AB-TCD) haploidentical HCT. Patients ≥10 years had significantly worse DFS. Conditioning for AB-TCD HCT typically includes rATG (Thymoglobulin®) 3 mg/kg/day on days -12 to -10. Models of rATG pharmacokinetics (PK) show slower clearance in older children. We hypothesized worse DFS seen in older patients may be due to excessive in vivoT-cell depletion by residual rATG post HCT.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Volume :
- 142
- Issue :
- 1, Number 1 Supplement 1
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs64590122
- Full Text :
- https://doi.org/10.1182/blood-2023-178925