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Isolation and Structure Determination of Akunolides, Macrolide Glycosides from a Marine Okeaniasp. Cyanobacterium
- Source :
- Journal of Natural Products; November 2023, Vol. 86 Issue: 11 p2529-2538, 10p
- Publication Year :
- 2023
-
Abstract
- Akunolides A (1), B (2), C (3), and D (4), new macrolide glycosides, were isolated from a marine Okeaniasp. cyanobacterium. Their structures were elucidated by spectroscopic analyses and derivatization reactions. Akunolides A–D (1–4) are classified as 16-membered macrolide glycosides, which are relatively rare structures for marine cyanobacterium-derived natural products. Akunolides A–D (1–4) showed moderate antitrypanosomal activities against Trypanosoma brucei rhodesiense, with IC50values ranging from 11 to 14 μM. Furthermore, akunolides A (1) and C (3) exhibited no cytotoxicity against normal human WI-38 cells even at a concentration of 150 μM.
Details
- Language :
- English
- ISSN :
- 01633864 and 15206025
- Volume :
- 86
- Issue :
- 11
- Database :
- Supplemental Index
- Journal :
- Journal of Natural Products
- Publication Type :
- Periodical
- Accession number :
- ejs64456496
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.3c00742