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Effect of colchicine on perioperative atrial fibrillation and myocardial injury after non-cardiac surgery in patients undergoing major thoracic surgery (COP-AF): an international randomised trial
Authors :
Conen, David Ke Wang, Michael Popova, Ekaterine Chan, Matthew T V Landoni, Giovanni Cata, Juan P Reimer, Cara McLean, Sean R Srinathan, Sadeesh K Reyes, Juan Carlos Trujillo Grande, Ascension Martín Tallada, Anna Gonzalez Sessler, Daniel I Fleischmann, Edith Kabon, Barbara Voltolini, Luca Cruz, Patrícia Maziak, Donna E Gutiérrez-Soriano, Laura McIntyre, William F Tandon, Vikas Martínez-Téllez, Elisabeth Guerra-Londono, Juan Jose DuMerton, Deborah Wong, Randolph H L McGuire, Anna L Kidane, Biniam Roux, Diego Parise Shargall, Yaron Wells, Jennifer R Ofori, Sandra N Vincent, Jessica Xu, Lizhen Li, Zhuoru Eikelboom, John W Jolly, Sanjit S Healey, Jeff S Devereaux, P J Conen, David Devereaux, PJ Vincent, Jessica Wang, Michael Ke Wells, Jennifer R. Healey, Jeff S. Landoni, Giovanni McIntyre, William F. Popova, Ekaterine Sessler, Daniel I. Srinathan, Sadeesh K. Amir, Mohammed Bangdiwala, Shrikant I. Bossard, Matthias Chan, Matthew TV Eikelboom, John W. Fleischmann, Edith Jolly, Sanjit Montes, Felix Ramón Reimer, Cara Schmartz, Denis Wang, Chew Yin Ofori, Sandra N. Blum, Steffen Alvarez-Garcia, Jesus Lo Bianco, Giuliana Traquair, Hugh Guerrero-Pinedo, Fernando Andres Oleynick, Christopher Meyre, Pascal B. Méndez-Zurita, Francisco Chiarella-Redfern, Helene Marcucci, Maura Donati, Francesco Gonzalez-Osuna, Aranzazu Minervini, Fabrizio Moreno Weidmann, Zoraida Guerra-Ramos, Jose M. Dion, Gabriel Ramos-Pachón, Anna Borges, Flavia K. de Sa Boasquevisque, Danielle Mosconi, Maria Giulia Amarenco, Pierre Mitchell, L. Brent Wyse, George Cheng, Davy McAlister, Finlay A. Wells, George A. Baskaran, Geethan Burns, Andrew T. Gennaccaro, Julia Howe, Rosemary Mastrangelo, Louise Pettit, Shirley Popovic, Michelle Shahbaz, Subana Tosh, Makayla Zucchetto, Simona J. Heenan, Laura Lee, Shun Fu Li, Zhuoru Xu, Lizhen Kabon, Barbara Hoetzenecker, Konrad Schweiger, Thomas Reiterer, Christian Zotti, Oliver Bsuchner, Paul Hochreiter, Beatrix Taschner, Alexander Adamowitsch, Nikolas Horvath, Katharina Hantáková, Nicole Bidgoli, Javad Huybrechts, Isabelle Cappeliez, Serge Neary, John D. Shargall, Yaron Tandon, Vikas Finley, Christian Agzarian, John Hanna, Waël Abdulrahman, Muammar Lawrence, Kelly Gregus, Krysten Quraishi, Faraaz Wikkerink, Spencer Wallace, Christine Prine, Merissa Gregus, Emily Hare, Jacqueline Lombardo, Kristen Fezia, Behashta Columbus, Teresa Rushton, Jacob DuMerton, Deborah Reid, Ken Parlow, Joel Chung, Wiley Karizhenskaia, Maria Malik, Aftab Tanzola, Rob Giles, Andrew McLean, Sean R. McGuire, Anna Lohser, Jens Lim, Shirley Grey, Rebecca Yee, John Grant, Kyle Lee, Alex L. Choi, James J. Dewar, Leith R. Durkin, Christopher Schisler, Travis Hecht, Patrick Hughes, Bevan Kidane, Biniam Liu, Richard Tan, Lawrence Gowing, Stephen Buduhan, Gordon Enns, Stephanie Poole, Emma Graham, Kristin Dubik, Niina Chin, Alex Maziak, Donna E. Seely, Andrew JE Gilbert, Sebastien Villeneuve, P. James Sundaresan, Sudhir Gingrich, Molly Fazekas, Anna Bucciero, Kirby Malthaner, Richard A. Lewis, Deb Fortin, Dalilah Qiabi, Mehdi Nayak, Rahul Plourde, Madelaine Marie Haider, Tehmina Murphy, Rowan Sellers, Daniel Donahoe, Laura Lefebvre, Marco Lanthier, Luc Ko, Michael Augustine Parente, David Cheung, Victoria Schieman, Colin Bessissow, Amal Wong, Randolph HL Joynt, Gavin M. Lam, Carmen KM Lau, Rainbow WH Wan, Innes YP Underwood, Malcolm J. Wu, William KK Wong, Wai Tat Choi, Gordon YS Lee, Eva Hui, Ka Yan Fung, Beaker Chan, Chee Sam Ng, Fung Kei Thung, Kin Hoi Gutiérrez-Soriano, Laura Castañeda, Laura Carmenza Téllez, Luis Jaime Ortiz-Ramirez, Lina Marcela Baiardo-Redaelli, Martina Belletti, Alessandro Dieci, Elisa Monaco, Fabrizio Muriana, Piergiorgio Nakhnoukh, Cristina Novellis, Pierluigi Turi, Stefano Viscardi, Stefano Veronesi, Giulia Voltolini, Luca Bongiolatti, Stefano Salvicchi, Alberto Gatteschi, Lavinia Indino, Rossella Tombelli, Simone Ravasin, Alice Salimbene, Ottavia Rosboch, Giulio Luca Balzani, Eleonora Ceraolo, Edoardo Neitzert, Luca Brazzi, Luca Londero, Francesco Grossi, William Massullo, Domenico Fiorelli, Silvia Margaritora, Stefano Hashim, Shahrul Amry Krishnasamy, Sivakumar See, Woan Shiang Nawaz, Mohammed Asghar Bilal, Haris Trujillo Reyes, Juan Carlos Martínez-Téllez, Elisabeth Belda Sanchis, Josep Planas Canovas, Georgina Libreros Niño, Alejandra Parera Ruiz, Ana Cladellas Gutierrez, Esther Guarino, Mauro Urrutia Cuchi, Gerard Argilaga Nogues, Marta Rovira Juan, Anna Medina-Aedo, Melixa Turró Castillejo, Mª Asunción Gil Sanchez, Josep Mª Araúz-Sarmiento, Ibell Herranz Perez, Gracia Chavarria Murillo, Stephania Garcia-Osuna, Alvaro Rodriguez-Arias, Ainhoa Berga Garrote, Nuria Martín Grande, Ascension Parise Roux, Diego Gajate Martín, Luis De Pablo Pajares, Angélica Candela Toha, Angel Manuel Moreno Mata, Nicolás Muñoz Molina, Gema Caballero Silva, Usue Cabañero, Alberto Fra Fernandez, Sara Cavestany García-Matres, Cristina Simón, Luisa Montenegro, Cristina Pozo, Sergio Gonzàlez-Tallada, Anna González Suarez, Susana Ribas Ball, Montserrat De Nadal Clanchet, Miriam Pérez Vélez, Javier Cruz, Patrícia Sánchez-Pedrosa, Guillermo Duque, Patricia González, Guillermo Huerta, Luis Rodríguez, Laura Garutti, Ignacio Ruiz-Villa, Laura Martí-Ejarque, Maria del Mar Gili-Bueno, Mireia Maddio Vieyra, Ricardo Matias Fibla, Juan J. Durán, Núria de Temple Pla, Marina Rodríguez-Fuster, Alberto Bermejo-Martínez, Silvia Carramiñana, Albert Opitz, Isabelle Etienne, Harry Cata, Juan P. Guerra-Londono, Juan Jose Rajaram, Ravi Corrales, German Vaporciyan, Ara Mehran, Reza Sepesi, Boris Walsh, Garrett Rice, David Cukierman, Daniel S. Swisher, Stephen Marchant, Bryan E. Harris, Lynne C. Cusson, Bruce D. Miller, Scott A. Ayad, Sabry Araujo, Jorge Marquez-Roa, Leonardo Hofstra, Richard L. Wudel, Leonard J. Minear, Steven C. Teixeira, Camila Pimentel, Mario Popoff, Andrew M. Marsack, Kelly Meehan, Sarah Chen, Tzonghuei H. Essandoh, Michael Poppers, Jeremy S.
Source :
The Lancet; November 2023, Vol. 402 Issue: 10413 p1627-1635, 9p
Publication Year :
2023
Abstract
Higher levels of inflammatory biomarkers are associated with an increased risk of perioperative atrial fibrillation and myocardial injury after non-cardiac surgery (MINS). Colchicine is an anti-inflammatory drug that might reduce the incidence of these complications.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
402
Issue :
10413
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs64400196
Full Text :
https://doi.org/10.1016/S0140-6736(23)01689-6