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Cigarette smoking and the incidence of cervical intraepithelial neoplasia, grade III, and cancer of the cervix uteri.
- Source :
- American Journal of Epidemiology; February 1992, Vol. 135 Issue: 4 p341-346, 6p
- Publication Year :
- 1992
-
Abstract
- The relation between cigarette smoking and cervical intraepithelial neoplasia, grade III (CIN III), and cervical cancer was examined among a cohort of 6,812 women in Tromsö, Norway, between 1980 and 1989. During the 52,844 person-years of observation, 185 incident cases (177 women with CIN III and eight with cervical cancer) were recorded in the regional pathology registry. The age-adjusted incidence rates of CIN III and cervical cancer were 267/100,000 person-years among women who had never smoked, 183/100,000 person-years among exsmokers, and 476/100,000 person-years among current smokers. A multivariate model containing terms for age, marital status, and frequency of intoxication yielded a relative rate for current smokers compared with nonsmokers of 1.5 (95% confidence interval 1.0-2.2). Statistical trend tests for the number of cigarettes smoked per day (never, 1-14, and greater than or equal to 15 cigarettes), years of smoking (never, 1-9, and greater than or equal to 10 years), and age started smoking (less than 16, 16-18, 19-21, and greater than or equal to 22 years) all yielded significant results. These findings support the opinion that CIN III and cervical cancer are a smoking-related disease.
Details
- Language :
- English
- ISSN :
- 00029262 and 14766256
- Volume :
- 135
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- American Journal of Epidemiology
- Publication Type :
- Periodical
- Accession number :
- ejs64364106
- Full Text :
- https://doi.org/10.1093/oxfordjournals.aje.a116295