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Does nondifferential misclassification of exposure always bias a true effect toward the null value?

Authors :
Dosemeci, M
Wacholder, S
Lubin, J H
Source :
American Journal of Epidemiology; October 1990, Vol. 132 Issue: 4 p746-748, 3p
Publication Year :
1990

Abstract

The authors present some examples to demonstrate that in certain nondifferential misclassification conditions with polychotomous exposure variables, estimates of odds ratios for categories at intermediate level of risk can be biased away from the null or can change direction. In addition, the authors present two examples to demonstrate that the slope of the dose-response trend for the true distributions can change direction, creating a false inverse trend, even if the misclassification is nondifferential.

Details

Language :
English
ISSN :
00029262 and 14766256
Volume :
132
Issue :
4
Database :
Supplemental Index
Journal :
American Journal of Epidemiology
Publication Type :
Periodical
Accession number :
ejs64363555
Full Text :
https://doi.org/10.1093/oxfordjournals.aje.a115716