SUPER Score Contributes to Warning and Management in Early-Stage COVID-19

•The SUPER score has a good prognostic AUC (0.985), sensitivity (1.00) and specificity (0.92) for early detecting severe COVID-19 cases with optimal threshold 4.•The accuracy of SUPER score is equivalent to NEWS2 which was recommended by WHO to predict the severity and predict prognosis of COVID-19 patients.•Compared with COVID-19 patients with SUPER score<4, patients in high- risk group tended to have lower lymphocyte counts, IL-2, IL-4, and higher levels of fibrinogen, CRP, AST, and LDH.