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Cold exposure induces vaso-occlusion and pain in sickle mice that depend on complement activation
- Source :
- Blood; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- •Cold exposure induces complement activation and vaso-occlusive pain crisis in sickle mice.•Inhibition of C5a generation with anti-C5 or signaling with anti-C5aR antibody inhibits cold-induced VOE and hyperalgesia in sickle mice.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs64139579
- Full Text :
- https://doi.org/10.1182/blood.2022019282