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Angiotensin-converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease.
Angiotensin-converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease.
- Source :
- Nephrology Dialysis Transplantation; December 2001, Vol. 16 Issue: 12 p2323-2327, 5p
- Publication Year :
- 2001
-
Abstract
- Previous studies concerning Alu I/D polymorphism in the ACE gene and ADPKD severity have used the Alu genotypes as a representative of the true biological variable, namely ACE activity. However, wide individual and ethnic differences in the proportion of variance in ACE activity explained by the I/D genotype may have confounded these studies. This investigation examines the association between ADPKD severity and ACE in terms of plasma enzyme activity and I/D genotypes in individuals from three different countries.
Details
- Language :
- English
- ISSN :
- 09310509 and 14602385
- Volume :
- 16
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Nephrology Dialysis Transplantation
- Publication Type :
- Periodical
- Accession number :
- ejs63992856
- Full Text :
- https://doi.org/10.1093/ndt/16.12.2323