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Angiotensin-converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease.

Angiotensin-converting enzyme activity and the ACE Alu polymorphism in autosomal dominant polycystic kidney disease.

Authors :
Schiavello, T
Burke, V
Bogdanova, N
Jasik, P
Melsom, S
Boudville, N
Robertson, K
Angelicheva, D
Dworniczak, B
Lemmens, M
Horst, J
Todorov, V
Dimitrakov, D
Sulowicz, W
Krasniak, A
Stompor, T
Beilin, L
Hallmayer, J
Kalaydjieva, L
Thomas, M
Source :
Nephrology Dialysis Transplantation; December 2001, Vol. 16 Issue: 12 p2323-2327, 5p
Publication Year :
2001

Abstract

Previous studies concerning Alu I/D polymorphism in the ACE gene and ADPKD severity have used the Alu genotypes as a representative of the true biological variable, namely ACE activity. However, wide individual and ethnic differences in the proportion of variance in ACE activity explained by the I/D genotype may have confounded these studies. This investigation examines the association between ADPKD severity and ACE in terms of plasma enzyme activity and I/D genotypes in individuals from three different countries.

Details

Language :
English
ISSN :
09310509 and 14602385
Volume :
16
Issue :
12
Database :
Supplemental Index
Journal :
Nephrology Dialysis Transplantation
Publication Type :
Periodical
Accession number :
ejs63992856
Full Text :
https://doi.org/10.1093/ndt/16.12.2323