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Positive Predictive Value of Anti-GAD65 ELISA Cut-Offs for Neurological Autoimmunity

Authors :
Budhram, Adrian
Freeman, Erin
Bhayana, Vipin
Yang, Liju
Source :
The Canadian Journal of Neurological Sciences; September 2023, Vol. 50 Issue: 5 p766-768, 3p
Publication Year :
2023

Abstract

ABSTRACT:High anti-GAD65 levels associate with core manifestations of GAD65 neurological autoimmunity. ELISA cut-offs for high anti-GAD65 levels (>10,000 IU/ml in serum, >100 IU/ml in CSF) have been proposed that merit further evaluation. We reviewed patients who underwent anti-GAD65 ELISA for suspected autoimmune encephalitis and found values above these cut-offs to have a positive predictive value (PPV) for neurological autoimmunity of 88%. Anti-GAD65 values above proposed ELISA cut-offs have a reasonably high PPV for neurological autoimmunity in patients with suspected autoimmune encephalitis. Consideration of alternative diagnoses and corroboration with CSF can help flag potentially clinically irrelevant results and avoid patient misdiagnosis.

Details

Language :
English
ISSN :
03171671
Volume :
50
Issue :
5
Database :
Supplemental Index
Journal :
The Canadian Journal of Neurological Sciences
Publication Type :
Periodical
Accession number :
ejs63811778
Full Text :
https://doi.org/10.1017/cjn.2022.276