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Bioengineered human tissue regeneration and repair using endogenous stem cells
- Source :
- Cell Reports Medicine; August 2023, Vol. 4 Issue: 8
- Publication Year :
- 2023
-
Abstract
- We describe a general approach to produce bone and cartilaginous structures utilizing the self-regenerative capacity of the intercostal rib space to treat a deformed metacarpophalangeal joint and microtia. Anatomically precise 3D molds were positioned on the perichondro-periosteal or perichondral flap of the intercostal rib without any other exogenous elements. We find anatomically precise metacarpal head and auricle constructs within the implanted molds after 6 months. The regenerated metacarpal head was used successfully to surgically repair the deformed metacarpophalangeal joint. Auricle reconstructive surgery in five unilateral microtia patients yielded good aesthetic and functional results. Long-term follow-up revealed the auricle constructs were safe and stable. Single-cell RNA sequencing analysis reveal early infiltration of a cell population consistent with mesenchymal stem cells, followed by IL-8-stimulated differentiation into chondrocytes. Our results demonstrate the repair and regeneration of tissues using only endogenous factors and a viable treatment strategy for bone and tissue structural defects.
Details
- Language :
- English
- ISSN :
- 26663791
- Volume :
- 4
- Issue :
- 8
- Database :
- Supplemental Index
- Journal :
- Cell Reports Medicine
- Publication Type :
- Periodical
- Accession number :
- ejs63762403
- Full Text :
- https://doi.org/10.1016/j.xcrm.2023.101156