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Electroactive membrane fusion-liposome for increased electron transfer to enhance radiodynamic therapy
- Source :
- Nature Nanotechnology; December 2023, Vol. 18 Issue: 12 p1492-1501, 10p
- Publication Year :
- 2023
-
Abstract
- Dynamic therapies have potential in cancer treatments but have limitations in efficiency and penetration depth. Here a membrane-integrated liposome (MIL) is created to coat titanium dioxide (TiO2) nanoparticles to enhance electron transfer and increase radical production under low-dose X-ray irradiation. The exoelectrogenic Shewanella oneidensisMR-1 microorganism presents an innate capability for extracellular electron transfer (EET). An EET-mimicking photocatalytic system is created by coating the TiO2nanoparticles with the MIL, which significantly enhances superoxide anions generation under low-dose (1 Gy) X-ray activation. The c-type cytochromes-constructed electron channel in the membrane mimics electron transfer to surrounding oxygen. Moreover, the hole transport in the valence band is also observed for water oxidation to produce hydroxyl radicals. The TiO2@MIL system is demonstrated against orthotopic liver tumours in vivo.
Details
- Language :
- English
- ISSN :
- 17483387 and 17483395
- Volume :
- 18
- Issue :
- 12
- Database :
- Supplemental Index
- Journal :
- Nature Nanotechnology
- Publication Type :
- Periodical
- Accession number :
- ejs63692409
- Full Text :
- https://doi.org/10.1038/s41565-023-01476-2