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Metal-ligand cooperative iridium complex catalyzed C-alkylation of oxindole and 1,3-dimethylbarbituric acid using alcohols
- Source :
- Green Synthesis and Catalysis; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- A general and high-efficiency C-alkylation of oxindoles and barbituric acids has been developed by a Cp∗Ir complex [Cp∗Ir (2,2′-bpyO)(OH)]Na with a bipyridine-based functional ligand. In particular, H2O was selected as the solvent instead of the organic solvent in this catalytic system. Through mild reaction conditions gave a variety of corresponding alkylated heterocyclic compounds with good to excellent yields. More importantly, the gram-scale C-alkylation reaction was successfully carried out with good yield using a common route with only a single purification by column chromatography.
Details
- Language :
- English
- ISSN :
- 26665549
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Green Synthesis and Catalysis
- Publication Type :
- Periodical
- Accession number :
- ejs63673096
- Full Text :
- https://doi.org/10.1016/j.gresc.2022.07.002