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Comparison of Endotoxin Activity Assay and Various Biomarkers for Severity Assessment in Colorectal Perforation Patients

Authors :
Matsuda, Kazuhiro
Aoki, Takeshi
Watanabe, Makoto
Tomioka, Kodai
Tashiro, Yoshihiko
Tomokazu, Kusano
Koizumi, Tomotake
Satoru, Goto
Yamazaki, Kimiyasu
Otsuka, Koji
Murakami, Masahiko
Source :
The American Surgeon; June 2023, Vol. 89 Issue: 6 p2854-2856, 3p
Publication Year :
2023

Abstract

Colorectal perforation is a serious disease with high mortality requiring emergency surgery. This study aimed to evaluate the role of the endotoxin activity assay (EAA) to assess the severity in patients admitted to the intensive care unit after emergency surgeries for colorectal perforations. Patients were divided into high (EAA ≥.4) and low (EAA <.4) groups based on the EAA levels, and the correlation between the EAA values and clinical variables related to the severity was evaluated. The SOFA scores were significantly higher in the high group than those in the low group. The high EAA value persisted even after 48 hours and extended the ICU length of stay. These results suggest that EAA may be a potential biomarker to assess severity and useful as one of the instrumental in predicting the outcomes for colorectal perforation patients.

Details

Language :
English
ISSN :
00031348 and 15559823
Volume :
89
Issue :
6
Database :
Supplemental Index
Journal :
The American Surgeon
Publication Type :
Periodical
Accession number :
ejs63627434
Full Text :
https://doi.org/10.1177/00031348211056256