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Anti-myeloma efficacy of CAR-iNKT is enhanced with a long-acting IL-7, rhIL-7-hyFc

Authors :
O’Neal, Julie
Cooper, Matthew L.
Ritchey, Julie K.
Gladney, Susan
Niswonger, Jessica
González, L. Sofía
Street, Emily
Haas, Gabriel J.
Carter, Alun
Amayta, Parmeshwar N.
Gao, Feng
Lee, Byung Ha
Choi, Donghoon
Berrien-Elliott, Melissa
Zhou, Alice
Fehniger, Todd A.
Rettig, Mike P.
DiPersio, John F.
Source :
Blood Advances; October 2023, Vol. 7 Issue: 20 p6009-6022, 14p
Publication Year :
2023

Abstract

•Human BCMA CAR-iNKTs show in vivo efficacy in a myeloma xenograft model that can be enhanced by a long-acting IL-7, rhIL-7-hyFc.•CAR-iNKTs may have lower CRS risk than CAR-Ts.

Details

Language :
English
ISSN :
24739529 and 24739537
Volume :
7
Issue :
20
Database :
Supplemental Index
Journal :
Blood Advances
Publication Type :
Periodical
Accession number :
ejs63482641
Full Text :
https://doi.org/10.1182/bloodadvances.2023010032