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Self-administered intranasal etripamil using a symptom-prompted, repeat-dose regimen for atrioventricular-nodal-dependent supraventricular tachycardia (RAPID): a multicentre, randomised trial
Authors :
Stambler, Bruce S Camm, A John Alings, Marco Dorian, Paul Heidbuchel, Hein Houtgraaf, Jaco Kowey, Peter R Merino, Jose L Mondésert, Blandine Piccini, Jonathan P Pokorney, Sean D Sager, Philip T Verma, Atul Wharton, J Marcus Bharucha, David B Plat, Francis Shardonofsky, Silvia Chen, Michael Ip, James E Ip, James E Jones, Alonzo Stambler, Bruce S Schleinkofer, David E Winters, Stephen Lam, Wilson Goldstein, Robert Dor, Isaac Dor Talwar, Sandeep O'Neill, Padraig G Koren, Michael J Beinart, Sean C Ambati, Srivani Mazer, Sean P Kinn, Robert M Roy, Karine Manshadi, Ramin Kuk, Richard Verma, Aditya Phelan, Timothy Stoian, Alexandru A Ellenbogen, Kenneth Jayachandran, J Vijay Connelly, Terence P Daccarett, Marcos Gandhi, Gaurang Mittal, Suneet Abdel-Wahab, Amir Augostini, Ralph Ip, John H Sorrentino, Denise Roux, Jean-Francois Brar, Ramandeep Khoo, Clarence Bennett, Matthew Lo, Eric Coutu, Benoit Sterns, Laurence Greer, Gerald S Gujja, Pradeep Gianfagna, Robert A Swarup, Vijendra Sogade, Felix Wilton, Stephen Ruisi, Christopher Barbera, Saverio Banchs, Javier E. Korley, Victoria Schulze, Christopher Damle, Roger Healey, Jeffrey Sean Pandey, A Shekhar Anderson, Jeffrey L Venkatachalam, K L Noseworthy, Peter Mondésert, Blandine Verma, Atul Friars, Douglas G Kambur, Thomas R Lockwood, Evan Meininger, Glenn Olsovsky, Greg Jones Sr, Alonzo Greer, Gerald Mehta, Rohit Akbar, Saleem Salman, Malik Rama, Bhola Arora, Ramesh Shah, Dhirenkumar Shah, Rakesh Cammarata, Michael Owens, Andrew Ludington, Katherine Wharton, Marcus Bagheri, Michael Khan, Mohammed Carr, Kenneth Warren Siddique, Sultan Parvathaneni, Sunthosh Devabhaktuni, Subodh Mouhaffel, Assad Mark, George Di Biase, Luigi Rangappa, Sunil Morton, Jared Yarmohammadi, Hirad Karim, Amin Martinez Fleites, Aldo Nero, Thomas Shafiq, Qaiser Coutu, Benoit Pandey, Shekhar Khaykin, Yaariv Joza, Jacqueline Gosselin, Gilbert Skanes, Allen Vyselaar, John Savard, Daniel Heidbuchel, Hein Xhaet, Olivier Catez, Emmanuel Vijgen, Johan Godart, Pascal Casado, Ruben Mairesse, Georges Rossenbacker, Tom Haemers, Peter Hoffer, Etienne Hausman, Pierre Vertes, Andras Duray, Gabor Szolnoki, Erzsebet Csanadi, Zoltan Lakatos, Ferenc Alings, Marco Dorman, Reinhart Tuininga, Y S Jansen, W Velthuis, Sebastiaan van Bemmel, B Bech, Gerhard Jan Willem Pisters, Ron Valk, Suzanne Romer, Tjeerd Luermans, Justin Beelen, Driek van Eck, Martijn Houtgraaf, Jaco Vet, Thijs Shellings, Dirk Oosterhof, T Miekus, Pawel Bebenek, Waldemar Bielecka-Dabrowa, Agata Gniot, Jacek Zmuda, Witold Kasprzak, Michal Balak, Wojciech Ptaszynski, Pawel Nowak, Jacek Prokopczuk, Janusz Przybylski, Andrzej Wozniak-Skowerska, Iwona Derejko, Pawel Czarnecka, Danuta Janas, Adam Merino Llorens, Jose Luis Tercedor, Luis Iniguez Romo, Andres Ruiz Granell, Ricardo Gonzalez Juanatey, Jose Ramon Pascual-Figal, Domingo Martinez-Selles, Manuel Anguera Camos, Ignacio Ibanez Criado, Alicia Matrinez Basterra, Javier Izquierdo, Alvaro Rivas Gandara, Nuria Alegret Colome, Josep M Perez Diez, Diego Martínez Hervás, Miguel Ángel Medina, Maria Segura Saint-Gerons, Jose María Pedrote Leal, Alonso Fernandez Lozano, Ignacio Quesada, Aurelio Guerra Ramos, Jose Sarrias, Axel Ramos Maqueda, Javier Mansourati, Jacques Defaye, Pascal Guedon-Moreau, Laurence Milhem, Antoine De Guillebon, Maxime Chevalier, Philippe Badoz, Marc Kriatselis, Charalampos Simonis, Gregor Lewalter, Thorsten Zarse, Markus Wilke, Andreas Kraemer, Fabian Al-Zoebi, Ayham
Source :
The Lancet; July 2023, Vol. 402 Issue: 10396 p118-128, 11p
Publication Year :
2023
Abstract
Etripamil is a fast-acting, intranasally administered calcium-channel blocker in development for on-demand therapy outside a health-care setting for paroxysmal supraventricular tachycardia. We aimed to evaluate the efficacy and safety of etripamil 70 mg nasal spray using a symptom-prompted, repeat-dose regimen for acute conversion of atrioventricular-nodal-dependent paroxysmal supraventricular tachycardia to sinus rhythm within 30 min.
Details
Language :
English
ISSN :
01406736 and 1474547X
Volume :
402
Issue :
10396
Database :
Supplemental Index
Journal :
The Lancet
Publication Type :
Periodical
Accession number :
ejs63477129
Full Text :
https://doi.org/10.1016/S0140-6736(23)00776-6