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Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality

Authors :
Molinaro, Antonio
Nemet, Ina
Bel Lassen, Pierre
Chakaroun, Rima
Nielsen, Trine
Aron-Wisnewsky, Judith
Bergh, Per-Olof
Li, Lin
Henricsson, Marcus
Køber, Lars
Isnard, Richard
Helft, Gerard
Stumvoll, Michael
Pedersen, Oluf
Smith, J. Gustav
Tang, W.H. Wilson
Clément, Karine
Hazen, Stanley L.
Bäckhed, Fredrik
Alves, Renato
Amouyal, Chloe
Andersson Galijatovic, Ehm Astrid
Andreelli, Fabrizio
Barthelemy, Olivier
Bastard, Jean-Philippe
Batisse, Jean-Paul
Berland, Magalie
Bittar, Randa
Blüher, Matthias
Bork, Peer
Bourron, Olivier
Camus, Mickael
Cassuto, Dominique
Ciangura, Cecile
Coelho, Luis Pedro
Collet, Jean-Philippe
Dumas, Marc-Emmanuel
Ehrlich, S. Dusko
Engelbrechtsen, Line
Fezeu, Leopold
Forslund, Sofia
Fromentin, Sebastien
Galan, Pilar
Giral, Philippe
Gøtze, Jens Peter
Hansen, Torben
Hansen, Tue H.
Hartemann, Agnes
Hartmann, Bolette
Hercberg, Serge
Holmes, Bridget
Holst, Jens Juul
Hornbak, Malene
Hoyles, Lesley
Hulot, Jean-Sebastien
Jaqueminet, Sophie
Kerneis, Mathieu
Khemis, Jean
Kozlowski, Ruby
Pedersen, Helle Krogh
Kuhn, Michael
Mannerås-Holm, Louise
Marko, Lajos
Martinez-Gili Robin Massey, Laura
Maziers, Nicolas
Medina-Stamminger, Jonathan
Moitinho-Silva, Lucas
Montalescot, Gilles
Moutel, Sandrine
Neves, Ana Luisa
Olanipekun, Michael
Oppert, Jean-Michel
Poitou, Christine
Pousset, Francoise
Pouzoulet, Laurence
Rouault, Christine
Silvain, Johanne
Vestergaard, Henrik
Source :
JACC: Heart Failure; July 2023, Vol. 11 Issue: 7 p810-821, 12p
Publication Year :
2023

Abstract

Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure.

Details

Language :
English
ISSN :
22131779
Volume :
11
Issue :
7
Database :
Supplemental Index
Journal :
JACC: Heart Failure
Publication Type :
Periodical
Accession number :
ejs63391658
Full Text :
https://doi.org/10.1016/j.jchf.2023.03.008