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Clinical utility of testing for PALB2and CHEK2c.1100delC in breast and ovarian cancer

Authors :
Woodward, Emma R.
van Veen, Elke M.
Forde, Claire
Harkness, Elaine F.
Byers, Helen J.
Ellingford, Jamie M.
Burghel, George J.
Schlech, Helene
Bowers, Naomi L.
Wallace, Andrew J.
Howell, Sacha J.
Howell, Anthony
Lalloo, Fiona
Newman, William G.
Smith, Miriam J.
Gareth Evans, D.
Source :
Genetics in Medicine; October 2021, Vol. 23 Issue: 10 p1969-1976, 8p
Publication Year :
2021

Abstract

To investigate the contribution of PALB2pathogenic gene variants (PGVs, PALB2_PGV) and the CHEK2c.1100delC (CHEK2_1100delC) PGV to familial breast and ovarian cancer, and PALB2_PGV associated breast cancer pathology.

Details

Language :
English
ISSN :
10983600 and 15300366
Volume :
23
Issue :
10
Database :
Supplemental Index
Journal :
Genetics in Medicine
Publication Type :
Periodical
Accession number :
ejs63385591
Full Text :
https://doi.org/10.1038/s41436-021-01234-6