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Pembrolizumab plus vorinostat is highly active in Hodgkin lymphoma, including cases refractory to prior PD-1 blockade

Authors :
Mei, Matthew
Chen, Lu
Godfrey, James
Song, Joo
Egelston, Colt
Budde, L. Elizabeth
Armenian, Saro
Nikolaenko, Liana
Guo, Weihua
Nwangwu, Mary
Gao, Lei
Lee, Peter
Chen, Robert
Daniels, Shari
Kennedy, Neena
Peters, Lacolle
Zain, Jasmine
Rosen, Steven
Forman, Stephen
Popplewell, Leslie
Kwak, Larry
Herrera, Alex F.
Source :
Blood; 20230101, Issue: Preprints
Publication Year :
2023

Abstract

•Pembrolizumab and vorinostat is well tolerated with a high ORR in RR cHL, with toxicities consistent with the known safety profiles of the 2 agents.•Pembrolizumab and vorinostat is active in RR cHL that is refractory to PD-1 blockade with an ORR of 56% in this subset.

Details

Language :
English
ISSN :
00064971 and 15280020
Issue :
Preprints
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs63384694
Full Text :
https://doi.org/10.1182/blood.2023020485