MRI Features for Identifying MYCN-amplified RB1Wild-type Retinoblastoma

Authors :: Jansen, Robin W.
Bloeme, Christiaan M. de
Cardoen, Liesbeth
Göricke, Sophia
Elst, Sabien van
Jessen, Jaime Lyn
Ramasubramanian, Aparna
Skalet, Alison H.
Miller, Audra K.
Maeder, Philippe
Uner, Ogul E.
Hubbard, G. Baker
Grossniklaus, Hans
Boldt, H. Culver
Nichols, Kim E.
Brennan, Rachel C.
Sen, Saugata
Sirin, Selma
Brisse, Hervé J.
Galluzzi, Paolo
Dommering, Charlotte J.
Castelijns, Jonas A.
Valk, Paul van der
Boellaard, Ronald
Dorsman, Josephine
Moll, Annette C.
Jong, Marcus C. de
Graaf, Pim de
Source :: Radiology; June 2023, Vol. 307 Issue: 5
Publication Year :: 2023
Abstract: MYCN-amplified RB1wild-type retinoblastoma has distinct features compared with RB1pathogenic variant–driven retinoblastoma at MRI, including tumors in a peripheral (anterior) location with plaque or pleomorphic shape, irregular margins, tumor-retinal folding, and peritumoral blood.

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