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Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT

Calcineurin inhibitor inhibits tolerance induction by suppressing terminal exhaustion of donor T cells after allo-HCT

Authors :
Senjo, Hajime
Harada, Shinpei
Kubota, Shimpei I.
Tanaka, Yuki
Tateno, Takahiro
Zhang, Zixuan
Okada, Satomi
Chen, Xuanzhong
Kikuchi, Ryo
Miyashita, Naoki
Onozawa, Masahiro
Goto, Hideki
Endo, Tomoyuki
Hasegawa, Yuta
Ohigashi, Hiroyuki
Ara, Takahide
Hasegawa, Yoshinori
Murakami, Masaaki
Teshima, Takanori
Hashimoto, Daigo
Source :
Blood; August 2023, Vol. 142 Issue: 5 p477-492, 16p
Publication Year :
2023

Abstract

•Calcineurin inhibitor treatment after allo-HCT suppresses differentiation of terminal Tex and induces transitory Tex.•Transitory Tex maintains responsiveness of donor T cells to PD-1 blockade and causes cGVHD after adoptive transfer into secondary recipients.

Details

Language :
English
ISSN :
00064971 and 15280020
Volume :
142
Issue :
5
Database :
Supplemental Index
Journal :
Blood
Publication Type :
Periodical
Accession number :
ejs63138589
Full Text :
https://doi.org/10.1182/blood.2023019875