Back to Search
Start Over
Direct Tissue PCR and Genotyping for Species Identification in a Case of Laryngeal Blastomycosis
- Source :
- Ear, Nose & Throat Journal; April 2023, Vol. 102 Issue: 4 pNP157-NP160, 4p
- Publication Year :
- 2023
-
Abstract
- Otolaryngologic manifestations of infection with Blastomycesspecies are extremely rare and restricted geographically to recognized endemic regions. Here, we describe a case of laryngeal blastomycosis that presented as slowly progressive dysphonia. While a preliminary diagnosis was made using routine histopathology, a species identification of Blastomyces dermatitidiswas made using polymerase chain reaction amplification and rapid genotyping without the need for fungal culture. All symptoms resolved following 1 month of antifungal therapy. Rapid molecular differentiation of B dermatitidisfrom Blastomyces gilchristiiprovides important insights into pathogenesis given recent recognition of differences in clinical spectra.
Details
- Language :
- English
- ISSN :
- 01455613 and 19427522
- Volume :
- 102
- Issue :
- 4
- Database :
- Supplemental Index
- Journal :
- Ear, Nose & Throat Journal
- Publication Type :
- Periodical
- Accession number :
- ejs62961866
- Full Text :
- https://doi.org/10.1177/0145561321991342