IL-7 receptor expression is frequent in T-cell acute lymphoblastic leukemia and predicts sensitivity to JAK inhibition

Authors :: Courtois, Lucien
Cabannes-Hamy, Aurélie
Kim, Rathana
Delecourt, Marine
Pinton, Antoine
Charbonnier, Guillaume
Feroul, Mélanie
Smith, Charlotte
Tueur, Giulia
Pivert, Cécile
Balducci, Estelle
Simonin, Mathieu
Angel, Laure Hélène
Spicuglia, Salvatore
Boissel, Nicolas
Andrieu, Guillaume P.
Asnafi, Vahid
Rousselot, Philippe
Lhermitte, Ludovic
Source :: Blood; July 2023, Vol. 142 Issue: 2 p158-171, 14p
Publication Year :: 2023
Abstract: •IL-7R/CD127 expression is frequent in T-ALL (∼70%) and aberrantly diverges from normal thymocytic development.•IL-7R/CD127 expression predicts sensitivity to JAK inhibition in T-ALL and synergism with BCL2 inhibition.

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