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TREM2 acts as a receptor for IL-34 to suppress acute myeloid leukemia in mice
- Source :
- Blood; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- •IL-34 is produced by mechanistic target of rapamycin complex 1-overactivated osteoclasts and suppresses AML in various preclinical models.•TREM2 is a novel receptor for IL-34 to induce myeloid differentiation by inhibiting ERK1/2/Rasal3 signaling.
Details
- Language :
- English
- ISSN :
- 00064971 and 15280020
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Blood
- Publication Type :
- Periodical
- Accession number :
- ejs62737664
- Full Text :
- https://doi.org/10.1182/blood.2022018619