Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation

In this study, Păun et al. describe how pioneer transcription factor ASCL1 regulates activation of gene regulatory elements involved in neuronal differentiation. They also show that ASCL1 interacts with the ATPase-dependent mSWI/SNF complex, elucidating a new mechanism of chromatin remodeling in human neurogenesis.