Adaptation to spindle assembly checkpoint inhibition through the selection of specific aneuploidies

In this study, Adell et al. investigated the bases of the selection of certain aneuploidy patterns in tumors, and by establishing time-resolved long-term adaptation protocols, they found that human cells adapt to persistent spindle assembly checkpoint (SAC) inhibition by acquiring specific chromosome arm gains and losses. They conclude that aneuploidy-induced gene dosage imbalances of individual mitotic regulators are sufficient for altering mitotic timing to reduce CIN.