The ChemoArchiChip: Interrogating the response of macrophages to the chemistry and geometry of microscale 3D objects

Effective integration of biomedical implants requires understanding and control of interactions between cells and the implant surface. High-throughput screening and modeling can identify properties that elicit desired cell behaviors and reveal patterns to underpin the future development of general design rules. Recently in Matter, Vassey et al. developed the ChemoArchiChip to investigate effects of microscale 3D objects with varied material chemistry on the adhesion and polarization of macrophages. The study shows the power of screening and modeling to generate understanding of cell-biomaterial interactions and provides specific knowledge of conditions to modulate the macrophage response.