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Redox Neutral Radical-Relay Nickel-Catalyzed Remote Carbonylation
- Source :
- Organic Letters; 20230101, Issue: Preprints
- Publication Year :
- 2023
-
Abstract
- A novel and efficient method for the catalytic installation of a carbonyl group via remote radical coupling is disclosed. The nickel-catalyzed reaction proceeds to undergo a sequential single-electron transfer, 1,5-hydrogen atom transfer, and carbonyl insertion, thus providing the α-substituted ketone. Further, this reaction could be carried out smoothly under normal pressure and redox-neutral conditions, and demonstrated functional-group compatibility and excellent site-selectivity.
Details
- Language :
- English
- ISSN :
- 15237060 and 15237052
- Issue :
- Preprints
- Database :
- Supplemental Index
- Journal :
- Organic Letters
- Publication Type :
- Periodical
- Accession number :
- ejs62654307
- Full Text :
- https://doi.org/10.1021/acs.orglett.3c00654