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Association between multidimensional prognostic index (MPI) and infections in a population of older people affected by COVID-19
- Source :
- Aging: Clinical and Experimental Research; May 2023, Vol. 35 Issue: 5 p1139-1143, 5p
- Publication Year :
- 2023
-
Abstract
- Background: Only limited studies analyzed a possible relationship between frailty and infections. Our aim was to investigate the possible association between higher multidimensional prognostic index (MPI) values, a tool for evaluating multidimensional frailty, and the prevalence of infectious diseases, including antibiotics’ cost and the prevalence of MDR (multidrug resistance) pathogens. Methods: Older patients, affected by COVID-19, were enrolled in the hospital of Palermo over four months. Results: 112 participants (mean age 77.6, 55.4% males) were included. After adjusting for potential confounders, frailer participants had a higher odds of any positivity to pathogens (prevalence: 61.5%, odds ratio = 15.56, p< 0.0001) compared to a prevalence of 8.6% in more robust, including MDR, and a higher costs in antibiotics. Conclusions: Higher MPI values, indicating frailer subjects, were associated with a higher prevalence of infections, particularly of MDR pathogens, and a consequent increase in antibiotics’ cost.
Details
- Language :
- English
- ISSN :
- 15940667 and 17208319
- Volume :
- 35
- Issue :
- 5
- Database :
- Supplemental Index
- Journal :
- Aging: Clinical and Experimental Research
- Publication Type :
- Periodical
- Accession number :
- ejs62626164
- Full Text :
- https://doi.org/10.1007/s40520-023-02386-y