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How Well do Polygenic Risk Scores Identify Men at High Risk for Prostate Cancer? Systematic Review and Meta-Analysis
- Source :
- Clinical Genitourinary Cancer; April 2023, Vol. 21 Issue: 2 p316.e1-316.e11, 28451p
- Publication Year :
- 2023
-
Abstract
- •Polygenic risk scores (PRS) can be used to predict risk of prostate cancer (PCa).•Based on meta-analysis, the ability of PRS to identify PCa was modest (AUC 0.63).•Combining PRS with clinical variables increased the pooled AUC to 0.74 (0.68-0.81).•PRS accuracy is comparable to PSA or family history.
Details
- Language :
- English
- ISSN :
- 15587673
- Volume :
- 21
- Issue :
- 2
- Database :
- Supplemental Index
- Journal :
- Clinical Genitourinary Cancer
- Publication Type :
- Periodical
- Accession number :
- ejs62619252
- Full Text :
- https://doi.org/10.1016/j.clgc.2022.09.006