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OP-4 IMPLEMENTATION OF A RE-LINKAGE TO CARE STRATEGY IN PATIENTS WITH CHRONIC HEPATITIS C WHO WERE LOST TO FOLLOW-UP IN LATIN AMERICA

Authors :
Mendizabal, Manuel
Thompson, Marcos
Gonzalez-Ballerga, Esteban
Anders, Margarita
Castro-Narro, Graciela E
Pessoa, Mario G
Cheinquer, Hugo
Mezzano, Gabriel
Palazzo, Ana
Ridruejo, Ezequiel
Descalzi, Valeria
Velasco, Jose A Velarde-Ruiz
Marciano, Sebastian
Muñoz, Linda
Schinoni, Maria I
Poniachik, Jaime
Perazzo, Rosalía
Cerda, Eira
Fuster, Francisco
Varon, Adriana
García, Sandro Ruiz
Soza, Alejandro
Cabrera, Cecilia
Gomez-Aldana, Andres J
Beltrán, Flor de María
Gerona, Solange
Cocozzella, Daniel
Bessone, Fernando
Hernández, Nelia
Alonso, Cristina
Ferreiro, Melina
Antinucci, Florencia
Torre, Aldo
Moutinho, Bruna D
Borges, Silvia Coelho
Gomez, Fernando
Murga, Maria Dolores
Piñero, Federico
Sotera, Gisela F
Ocampo, Jhonier A
Mollinedo, Valeria A Cortés
Girala, Marcos
Montes, Pedro
Ratusnu, Natalia
Zuñagua, Claudia A
Castillo, Lida
Barradas, Mauricio Castillo
Chávez, Rocío
Ivantes, Cláudia
Brutti, Julia
Tenorio, Laura
Garavito, Jorge
Zevallos, Katherine
Contreras, Fernando
Infante, Mirtha
Vera-Pozo, Emilia
Tagle, Martín
Toro, Luis G
Rocha, Carlos A De La
Simian, Daniela
Silva, Marcelo O
Source :
Annals of Hepatology; March 2023, Vol. 28 Issue: 1, Number 1 Supplement 1
Publication Year :
2023

Abstract

To achieve WHO's goal of eliminating HCV, innovative strategies must be designed to diagnose and treat more patients. This study aimed to describe an implementation strategy to identify patients with HCV who were lost to follow-up (LTFU) and offer them re-linkage to Figure 1. Analysis of global DNA methylation. A) Representative dot blot using anti-5mC which recognizes global methylated DNA, anti-IgG as negative control and methylene blue staining as total DNA loading control. B) Graphs shows mean ± standard deviation of 5mC densitometry brand intensity of study groups. C) Graph that represents the percentage of global methylation of the DNA analyzed with ELISA.A one-way ANOVA statistical test and a Tukey post hoc test were performed. Group NT: only received vehicle; Group HCC: damage group induced by weekly administration of DEN and 2-AAF for 12 weeks; and Group HCC/PFD: which received the same treatment as Group HCC, plus PFD (300 mg/kg) (**p<0.005)Figure 1. Analysis of global DNA methylation. A) Representative dot blot using anti-5mC which recognizes global methylated DNA, anti-IgG as negative control and methylene blue staining as total DNA loading control. B) Graphs shows mean ± standard deviation of 5mC densitometry brand intensity of study groups. C) Graph that represents the percentage of global methylation of the DNA analyzed with ELISA.A one-way ANOVA statistical test and a Tukey post hoc test were performed. Group NT: only received vehicle; Group HCC: damage group induced by weekly administration of DEN and 2-AAF for 12 weeks; and Group HCC/PFD: which received the same treatment as Group HCC, plus PFD (300 mg/kg) (**p<0.005)Figure 1. Analysis of global DNA methylation. A) Representative dot blot using anti-5mC which recognizes global methylated DNA, anti-IgG as negative control and methylene blue staining as total DNA loading control. B) Graphs shows mean ± standard deviation of 5mC densitometry brand intensity of study groups. C) Graph that represents the percentage of global methylation of the DNA analyzed with ELISA.A one-way ANOVA statistical test and a Tukey post hoc test were performed. Group NT: only received vehicle; Group HCC: damage group induced by weekly administration of DEN and 2-AAF for 12 weeks; and Group HCC/PFD: which received the same treatment as Group HCC, plus PFD (300 mg/kg) (**p<0.005)

Details

Language :
English
ISSN :
16652681
Volume :
28
Issue :
1, Number 1 Supplement 1
Database :
Supplemental Index
Journal :
Annals of Hepatology
Publication Type :
Periodical
Accession number :
ejs62594366
Full Text :
https://doi.org/10.1016/j.aohep.2023.101053