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Adenoviral penton and hexon proteins are equivalent immunogenic targets of virus-specific T cells after HSCT in children

Authors :
Wintering, Astrid
Tischer-Zimmermann, Sabine
Schultze-Florey, Rebecca
Beier, Rita
Sauer, Martin
Blasczyk, Rainer
Heim, Albert
Eiz-Vesper, Britta
Maecker-Kolhoff, Britta
Source :
Transplantation and Cellular Therapy; 20230101, Issue: Preprints
Publication Year :
2023

Abstract

•Penton is an important immunodominant T-cell antigen in HAdV reactivation after HSCT.•Both penton- and hexon-specific T cells play an essential role in HAdV control.•Characteristics of antiviral T-cell response were similar albeit individually distinct.•Routine immunomonitoring should include penton-specific T cells.

Details

Language :
English
ISSN :
26666375 and 26666367
Issue :
Preprints
Database :
Supplemental Index
Journal :
Transplantation and Cellular Therapy
Publication Type :
Periodical
Accession number :
ejs62565576
Full Text :
https://doi.org/10.1016/j.jtct.2023.03.013